Description

EUK***4 Ethylbisiminomethylguaiacol Manganese Chloride *********1

EUK***4
INCI Name: Ethylbisiminomethylguaiacol Manganese Chloride
CAS Number: *********1
Synonym: 2,2′-[1,*-Ethanediylbis(nitrilomethylidyne)]bis[*-methoxy-phenol manganese complex
 
Appearance:Dark brown to reddish powder
Solubility: H2O: 2 mg/mL, clear (warmed); Soluble in DMSO
storage temp: −*0°C
 
STORAGE
It should be protected from light, heat, oxygen and moisture. Keep container tightly closed. Once opened, useit quickly.
 
ADVANTAGES
Both superoxide dismutase (SOD) andcatalase (CAT) activities
Self-regenerating property
Smaller molecular weight
High stability
 
RECOMMENDED FOR
Skin care (Facial care, Facial cleansing, Body care, Baby care)
Sun care (Sun protection, After-sun & Self-tanning)
 
APPLICATIONS
Antioxidant
UV protection
Protect against DNA damage
DNA repair
Anti-inflammatory
Anti-irritation
Anti-stress
Sunscreen care, supplement the care that general sunscreen ingredients cant take care of
 
EUK***4 is a highly purified molecule and a multi-functional, super antioxidant and powerful free radical scavenger with self-regenerating property. It is asynthetic mimetic of two natural skin enzymes:catalase and superoxide dismutase.
It protects against free radicals, DNA damages and reduces erythema and redness.
It helps prevent premature aging and scavenges superoxide free radicals, eliminates hydrogene peroxide (H2O2) and transformsreactive oxygen species(ROS) into water and oxygen which are beneficial for the skin.
It protects skin tissue against toxic compounds, protects skin against UV-induced DNA damage leading to limit premature photo-aging.
It inhibits MMP*2, thus preserving a good ECM network.
It reduces damages caused by UV and skin free radical activity.
It is used in prevention of DNA damage,repair DNA,brighten skin tone,anti-irritant, anti-stress, anti-inflammatory, antioxidant and sun care products.
It is complementary to SPF ingredient.
 
EUK***4 has dual antioxidant function i.e. superoxide dismutase and catalase mimetic activities.Its therapeutic use and studies conducted are based on its property to reduce reactive oxygen species (ROS) induced cellular injury in the body. It is a  low-molecular-weight synthetic complex that has better potency, stability, and bioavailability than endogenous antioxidant enzymes.
EUK-**4can act as a scavenger for oxidative species such as hydrogen peroxide, peroxynitrite and superoxide. This compound is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity.
 
EUK***4 has the unique and amazing capacity of regenerating itself during its free radical scavenging action. Thereby, EUK***4, represents a complete nature mimetic antioxidant system that can be used as an active cosmetic ingredient to limit premature aging, reduce photo-aging, protect the skin and its DNA from sun damage and decrease redness.
 
MECHANISM OF ACTION
People consume food and water every day, transport them to various body tissues through the digestive system and circulatory system, and are metabolized in cells to release energy. During the entire metabolism process, a large number ofreactive oxygen species (ROS) will be produced, including: O2-, H2O2 and HO2-, -OH, etc. TheseROS can damage the normal cells of the human body, leading to cell apoptosis and even necrosis.
The two important antioxidant components in the human body are: superoxide dismutase (SOD) and catalase (CAT). These two components work closely together to convert the ROS  produced in the metabolic process into water and oxygen to maintain the bodys normal metabolism.
Due to the high molecular weight of SOD, it is difficult to penetrate the stratum corneum. In addition, even if SOD enters the skin in a small amount through pores and sweat glands, it is easily hydrolyzed by protein and has poor stability and fast metabolism in the human body. These characteristics of SOD prevent its application in cosmetics. Therefore, EUK***4 was developed to replace the application of SOD and CAT in the cosmetics field.
THERAPEUTIC EFFECTS OF EUK***4
Many inflammatory and non-inflammatory diseases, UV rays, pollutants, smoke, and radiation exposure can cause oxidative damage to the skin.
The synthetic SOD/ CATmimetic EUK***4 might be able to compensate for seasonal deficiencies in antioxidant defense capacity at the skin surface, protecting the skin against oxidative damage.
EUK***4 is now commercially available as an antioxidant for the protection of dry or irritated skin. It must not be used immediately with strong acids such as suspensions ofascorbicacid. Strong acids will completely destroy EUK***4 which is based on manganese.
NOTE: Please avoid EUK***4 if you have known hypersensitivity to manganese. Always do a patch test on the upper forearm with the product to test for possible allergic reaction.