Description

Product name: GHK-Cu(1:1)
CAS NO.: *********5
Sequence: Gly-His-Lys.Cu2+
M.W: **2.*2
M.F.: C*4H*2CuN6O4
Description: The human peptide GHK-Cu was isolated in ***3 by Pickart as an activity in human albumin that caused old human liver tissue to synthesize proteins like younger tissue. Subsequent studies established this activity as a tripeptide with an amino acid sequence glycyl-L-histidyl-L-lysine with a strong affinity for copper that readily formed the complex GHK-Cu. It was proposed that GHK-Cu functions as a complex with copper 2+. Pickart et al. have established that GHK-Cu accelerates wound healing and contraction, improves the take of transplanted skin, and also possesses antiinflammatory actions.Subsequent studies directed by Borel and Maquart et al. demonstrated that GHK-Cu at a very low, nontoxic concentration (**0 nanomolar) stimulated both synthesis and breakdown of collagen and glycosaminoglycans. GHK modulated an activity of both metalloproteinases and their inhibitors (TIMP*1 and TIMP*2), acting as a main regulator of wound healing and skin remodeling processes. GHK-Cu stimulated collagen, dermatan sulfate, chondroitin sulfate, and a small proteoglycan, decorin. In ***1 McCormack et al. established that GHK-Cu restored replicative vitality to fibroblasts from patients after anticancer radiation therapy that damages cellular DNA.Wound healing activity of GHK-Cu was confirmed in animal experiments. GHK-Cu accelerated wound healing and increased blood vessel formation and the level of antioxidant enzymes in rabbits. This molecule also induced systemic wound healing in rats, mice, and pigs. It improved the healing of diabetic and ischemic wounds in rats, decreasing the level of TNF-alpha and stimulating collagen synthesis. It also facilitated healing of pad wounds in dogs. Such well-documented skin regeneration activity prompted widespread use of GHK in antiaging cosmetic products.Recently, GHK-Cu has been gaining publicity as a prospective therapeutic agent for chronic obstructive pulmonary disease (COPD), skin inflammation, and metastatic colon cancer. It has been established that it is capable of up- and downregulating at least 4,**0 genes in the human genome, essentially resetting DNA back to a healthier state. These studies shed new light on the skin remodeling activity of the GHK-Cu peptide.

Format: blue powder or 1% solution.
​Package: 1Gram, *0Gram, **0Gram, 1KG(1% solution)