Description
1. Sources and
Habitation
Apigenin
(4,5,*-trihydroxyflavone), is a natural product belonging to
the flavoneclass that is the aglycone of
several naturally occurring glycosides.It is found in high
amounts in several herbs including parsley, thyme, and
peppermint.
It is is also found in a
number of other herbs, including chamomile herb, Horsetail herb,
lemon balm herb, perilla herb, vervain herb, and
yarrow.
Red wine and tomato
sauce contain this flavonoid.
2. Descriptions and
Specifications of Product
Plant original: Apium
graveolens var.dulce
Specifications: *8.0%
Apigenin Test by HPLC
Molecular Formula:
C*5H*0O5
Molecular Mass:
**0.*4
CAS No:
*******5
3. Indications and
Uses
Apigenin is an
antioxidant plant flavanoid which contains anti-inflammatory
and anticancer properties. It may induce apoptosis and
may inhibit proliferation of tumor cells by arresting the cell
cycle at the G2/M phase.
Apigenin Is
also known to be a MAP kinase inhibitor and a selective inhibitor
of Protein Kinase 2 (CK2). Apigenin is capable
of exerting
diverse effects on a vast variety of molecular targets. Most
effects appear to be mostly mediated through suppressing nitric
oxide synthase*2 (NOS2), Hypoxia-inducible factor 1 α (HIF*1α),
lipoxygenase, cyclooxygenase*2 (COX*2) and vascular
endothelial growth factor (VEGF) expression. Blocks
proliferation of Wnt*1 transfected cells, dephosphorylates
β-catenin and lowers levels of β-catenin and Dvi. Apigenin is
an inhibitor of Casein Kinase, CYP*9, CYP2C9, ERK and
PKC.
4. Safety
Concerns
Apigenin seems to be
very safe chemical, without any dangerous side effects, flavonoid
can interact with chemotherapy
drugs.
It is, by itself, a
potent chemotherapeutic agent.
5. Dosage
Information
For general health and
well-being, doses found in multiple servings of fruits and
vegetables is adequate.For
anxiolytc effects, doses in the range of ***0 mg/kg
bodyweight are effective without sedation,
and higher doses induce sedation in addition to reductions in
anxiety.
The Information had not
been evaluated by the Food and Drug Administration, only for
reference
Jessie Lee | Sales Manager
Peace Fortune Enterprise Limited.
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