Description
Name Corni Fructus Extract
Latin Name Cornus officinalis seb.
Synonyms
Corni Fructus is Cornaceae Cornaceae,
Cornus was
born in thickets on slopes in habitat distribution.
Located in Shaanxi, Shanxi, Shandong, Anhui,
Zhejiang, Sichuan province. North Korea also has.
Plant part used fruit
Active Ingredient Loganin
Molecular Formula C
*7H
*6O
*0
Molecular Weight **0.*9 g/mol
Specification 7%, *0%, *0%
Test Method HPLC
CAS No. *********2
Study
Accumulating evidence indicates that uncontrolled
diabetes leads to the progression of diabetic complications such as
liver disorder. The present study was carried out to elucidate the
protective role of loganin extracted from Corni Fructus against
hepatic oxidative stress caused by type 2 diabetes. Loganin (*0 or
**0mg/kg body weight/day, p.o.) was administered every day for 8
weeks to db/db mice, and its effect was assessed on comparison with
vehicle-treated db/db and m/m mice. The administration of loganin
led to a decrease in glucose and elevation of leptin in serum. The
diabetic oxidative stress was attenuated by loganin through
inhibitions of reactive oxygen species production and lipid
peroxidation in the serum and liver. The expression of proteins
induced by oxidative stress was significantly up-regulated in the
liver of diabetic db/db mice; however, the expressions of both
Nox*4 and p*2(phox) were decreased significantly by loganin
administration. Loganin showed a crucial effect in the
inflammation-activated signaling pathway through the regulation of
NF-KB, COX*2, and iNOS. It was also found to regulate the
anti-inflammatory factors Nrf*2 and HO*1 in hepatic tissue.
Moreover, expression of MCP*1 was significantly down-regulated in
the loganin-treated db/db mice. Furthermore, loganin administration
showed a protective effect against apoptosis by the regulation of
Bcl*2 and cytochrome c. The present study demonstrated that the
administration of loganin isolated from Corni Fructus had a
protective effect against hepatic oxidative stress under type 2
diabetes through regulations of protein expressions related to
oxidative stress, inflammation, and apoptosis.
Main Function
Blood glucose effects *- Loganin have
antidiabetic effects, Loganin had significant hypoglycemic effect
on alloxan and adrenaline four diabetic rats.
Antibacterial *- loganin experiments showed that the fruit
of Cornus officinalis decoction can inhibit the growth of
Staphylococcus aureus, Escherichia coli, but the invalid.
Inhibitory effect on platelet aggregation *- Cornus
officinalis injection in vitro drug, can inhibit the threshold
concentration of two adenosine monophosphate ( ADP ) in rabbit
platelets sodium, collagen or four arachidonic acid induced
aggregation, inhibitory effect as its amount increased.
Usage Dietary supplement; Medicine.
Shelf Life 2 years
Storage
• Protected from light.
