Description
Secnidazole
CAS No.: ********8
Other Names: Alpha, *-Dimethyl**-nitro*1H-imidazole**-ethanol
MF: C7H*1N3O3
EINECS No.: ********0
Grade: Medicine Grade
Property:
White, similar to white or yellowish crystal or crystal powder,
odorless,
Bitter taste. Freely soluble in Ethanol, soluble in chloroform,
sparinglyoluble in water or ethyl ether, freely soluble in dilute
acid.
Description:
Secnidazole is structurally related to the commonly used 5
-nitroimidazoles metronidazole and tinidazole. These drugs share a
common spectrum of activity against anaerobic micro-organisms and
they appear particularly effective in the treatment of amoebiasis,
giardiasis, trichomoniasis and bacterial vaginosis.
Secnidazole is rapidly and completely absorbed after oral
administration and has a longer terminal elimination half-life
(approximately *7 to *9 hours) than commonly used drugs in this
class. In patients with intestinal amoebiasis or giardiasis,
clinical or parasistological cure rates of *0 to **0% are achieved
after treatment with a single dose of secnidazole 2g (*0 mg/kg in
children), similar to the response rates
Achieved with multiple dosage regimens of metronidazole or
tinidazole.
Applications:
Secnidazole is used to control the trichomonad, amebiasis.
