Rutin may also modulate the respiratory burst of neutrophils. The in vivo antioxidant activity of rutin is most likely due to its aglycone quercetin, to which it is metabolized following ingestion. Although most studies show rutin to inhibit lipid peroxidation, a few studies do not. Rutin may also help maintain levels of the biological antioxidant reduced glutathione. Importantly, under certain conditions, rutin or its metabolite quercetin may become a pro-oxidant. For example, nitrosation of rutin/ quercetin may produce a pro-oxidant molecule that may have mutagenic potential.

1.Rutin has strong antioxidant properties.

2.Rutin inhibits platelet aggregation, as well as decreasing capillary permeability, making the blood thinner and improving circulation.

3.Rutin has anti-inflammatory, preventive and healing effects.

4.Rutin inhibits aldose reductase activity. Aldose reductase is an enzyme normally present in the eye and elsewhere in the body. It helps change glucose into a sugar alcohol called sorbitol. Rutin also strengthens the capillaries, and, therefore, can reduce the symptoms of haemophilia.

5. Rutin, as ferulic acid, can reduce the cytotoxicity of oxidized LDL cholesterol and lower the risk of heart disease.

6.Rutin can be used to treat hemorrhoids, varicosis, and microangiopathy

7.Hydroxyethylrutosides, synthetic hydroxyethyl acetylations of rutin, are used in the treatment of chronic venous insufficiency.)

8.There are indications that rutin can inhibit some cancerous and pre-cancerous conditions.