Description

This substance has also been shown to reduce oxidative damage to DNA in vitro. Scientists exposed cells to *0 micromoles of naringenin per liter, for *4 hours, and found that the amount of hydroxyl damage to the DNA was reduced by *4% in that very short period of time.
Naringenin found in grapefruit juice has been shown to have an inhibitory effect on the human cytochrome P**0 isoform CYP1A2, which can change pharmacokinetics in a human (or orthologous) host of several popular drugs in an adverse manner, even resulting in carcinogens of otherwise harmless substances.
Naringenin has also been shown to reduce hepatitis C virus production by infected hepatocytes (liver cells) in cell culture. This seem to be secondary to Naringenin ability to inhibit the secretion of very-low-density lipoprotein by the cells. The antiviral effects of naringenin are currently under clinical investigation.
Naringenin seems to protect LDLR-deficient mice from the obesity effects of a high-fat diet.
Naringenin lowers the plasma and hepatic cholesterol concentrations by suppressing HMG-CoA reductase and ACAT in rats fed a high-cholesterol diet