Description
NOMENCLATURE
Common name dinotefuran (BSI; pa
ISO)
IUPAC name
(RS)**-methyl**-nitro**-(tetrahydro**-furylmethyl)guanidine
Chemical Abstracts name
N-methyl-N'-nitro-N''-[(tetrahydro**-furanyl)methyl]guanidine
CAS RN [**********0] Development codes MTI***6 (Mitsui)
PHYSICAL CHEMISTRY
Mol. wt. **2.2 M.f.
C7H*4N4O3 M.p. *4.****1.5 °C KOW logP = *0.**4 (pH
7) S.g./density 1.*3 Solubility In purified water
*4.3?.3 g/l (*0 °C). pKa No dissociation in range pH 1.4 to
*2.3
APPLICATIONS
Biochemistry Agonist
of the nicotinic acetylcholine receptor, affecting the synapses in
the insect central nervous system. Mode of action Active by
ingestion and by contact; also exhibits root-systemic
activity. Uses Controls a range of hemipterous and other
pests, at ******0 g/ha.
MAMMALIAN
TOXICOLOGY
Oral Acute oral LD*0 for male rats ***4,
female rats ***0, male mice ***0, female mice ***5 mg/kg.
Skin and eye Acute percutaneous LD*0 for male and female rats
>***0 mg/kg. Not a skin sensitiser (guinea pigs).
ECOTOXICOLOGY
Birds Acute oral LD*0 for
mallard ducks ***0, Japanese quail >***0 mg/kg. Fish LC*0
(*6 h) for carp >***0 ppm; (*8 h) for rainbow trout >*0
ppm. Daphnia (*8 h) ***0 ppm Other aquatic spp. LC*0
(*8 h) for crayfish ***0 ppm.
