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Factors affecting the properties of carbomer gel Factors affecting the properties of carbomer gel Factors affecting the properties of carbomer gel Factors affecting the properties of carbomer gel Factors affecting the properties of carbomer gel
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Factors affecting the properties of carbomer gel

( Negotiable )

|

20 Kilogram Minimum Order

País:

China

N º de Modelo:

DS-carbomer-26

Precio FOB:

( Negotiable ) Obtener el precio más reciente

Lugar de origen:

Ezhou city,Hubei province,china

Precio de pedido mínimo:

-

Cantidad de pedido mínimo:

20 Kilogram

Detalle de embalaje:

20kg/paper package

El tiempo de entrega:

4-10 days

Capacidad de suministro:

1000 Kilogram

Tipo de pago:

T/T, L/C

Grupo de productos :

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Miembro Básico

Persona de contacto jing zhao

Business Address:C8-2, Optics Valley United Technology City, Huarong District, Ezhou, Hubei

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Especificaciones del producto

  • Other Names: Carbomer 940;Carbomer 980
  • MF: C3H4O2
  • Purity (%): 99
  • Classification: General Reagents
  • Brand Name: Desheng
  • M.W.:72.06270
  • PH:2-3.5
  • Color:White
  • Appearance:Powder
  • Viscosity 1:0.2% Aqueous Solution:13000~30000mPa.s
  • Viscosity 2:0.5% Aqueous Solution:40000~60000mPa.s

Descripción del producto

Factors affecting the properties of carbomer gel

The carbomer we produce is a white loose powder with strong hygroscopicity. Therefore, it must be placed in a plastic bag in a dry place during storage. When we use carbomer, we usually make a gel and add it to daily chemicals or medical raw materials. What are the factors that affect the properties of carbomer gel? Including the pH value and ionic strength of the medium, the nature of the drug, and the presence of other excipients.
 
Factors affecting the properties of carbomer gel
1. The effect of pH
Since the carbomer polymer has a large number of free carboxyl groups, its pKa value is usually small. When the pH of the medium is less than 4, the carboxyl groups hardly dissociate, and when the pH>4, the carboxyl groups begin to dissociate, the polymer swells, and the viscosity increases. , When the pH value is 8, the dissociation is almost complete and the viscosity is the largest. When carbomer is used as a carrier for basic drugs, after the drug is dissolved, the pH of the medium increases, the degree of carbomer dissociation increases, the gel layer thickens, and the drug release rate decreases, so as to achieve the control of drug release purpose. The pH value of the medium also affects the adhesion of the carbomer gel. When the pH value is lower than its pKa, the gel has a stronger bonding ability and increased adhesion. At the same time, the ionic strength of the medium can change the sensitivity of the carbomer gel to pH. When the ionic strength is high, the carbomer is easier to release protons, and its pKa value decreases, so it can be dissociated and dissolved at a lower pH. rise.
 
2. Influence of ionic strength
In some drug delivery systems, the influence of the drug on the pH and ionic strength of the medium around the gel is not negligible, because the pH of the drug will also affect the properties of the gel, and the effect of acidic drugs is more obvious. The main drug is 2 In the case of *-dihydroxybenzoic acid, the thickness of the gel layer is about twice the thickness of the gel layer formed by salicylic acid as the main drug, which proves that acid drugs will increase the adhesion of the gel.
 
3. The influence of other excipients
In carbomer gel, if polyvinylpyrrolidone and polyoxyethylene are used as excipients at the same time, it may reduce the mucosal adhesion ability of carbomer gel. This decrease is also related to the concentration and molecular weight of coexisting excipients, and the concentration of excipients is high. (5%), can significantly reduce the adhesion of carbomer gel, when its concentration is reduced to 0.5%, the effect is small. Generally, the pH of the medium cannot change this property of polyvinylpyrrolidone and polyoxyethylene. Magnesium stearate can also reduce the adhesion of carbomer gel because of its hydrophobicity.

País: China
N º de Modelo: DS-carbomer-26
Precio FOB: ( Negotiable ) Obtener el precio más reciente
Lugar de origen: Ezhou city,Hubei province,china
Precio de pedido mínimo: -
Cantidad de pedido mínimo: 20 Kilogram
Detalle de embalaje: 20kg/paper package
El tiempo de entrega: 4-10 days
Capacidad de suministro: 1000 Kilogram
Tipo de pago: T/T, L/C
Grupo de productos : Carbomer

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jing zhao < Hubei xindesheng Material Technology Co., Ltd >

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