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urea is the principle waste product of protein catabolism.It is synthesized in the liver from ammonia which is produced as a result of the deamination of amino acids.Normally, urea nitrogenin the blood comprises only about  *5% of the nonprotein nitrogen. The importance of urea nitrogen determination is its value as as indicator of liver and kidney functions.Decreases in Blood Urea Nitrogen(BUN) are seen with nephritis,acute liver destruction,amyloidosis and pregnancy. Increases inBUN are encountered with acut and chronic nephritis,intestinal and urinary obstruction,uremia,metallic poisoning,pneumonia,Addison's disease,peritonitis,surgical shock and cardiac failure.