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 The skin permeability of ***0 molecular weight oligohyaluronic acid increased with time. After 6 hours, the skin permeability of ***0 molecular weight oligohyaluronic acid was *0.*2%, almost **0%. The permeability of **0KDa sodium hyaluronate was only 5.*4%, *4.*8% lower than ***0 molecular weight oligohyaluronic acid. It can be seen that ***0 molecular weight oligohyaluronic acid has strong skin penetration and can achieve deep moisturization of skin. 
The cell permeability of ***0Da oligohyaluronic acid increased significantly with time, and it was *4% after 6 hours. 
The cell permeability of ***0KDa sodium hyaluronate was not obvious, 0.*4% at 6 hours, which was lower than ***0Da oligomeric hyaluronic acid. 
*3.*6%. It can be seen that ***0Da oligohyaluronic acid not only has very strong skin permeability, but also penetrates deep cells. 
 Increase the number of p*3 positive cells and the regulation of integrin α 6 and β 1 
It can increase the thickness of epidermis and promote the differentiation of epidermis.