Piceatannol

Descripción del producto

Description

Piceatannol is a chemical compound with similar structure to resveratrol, being widely existed in vegetables such as grapes, blueberries and passion fruit. It is capable of inhibiting the growth of immature adipocytes, so as to achieve the purpose of weight loss. In addition, it also helps prevent cancer, heart disease and neurological diseases.

In early April ***2, researchers in Purdue University has published a new study in journal, finding that piceatannol can delay the production of new fat cells, and inhibit the growth of immature fat cells into mature cells, which can help control the obesity. The researchers also claim that while this study shows that red wine helps to lose weight, further research is needed to improve the stability and solubility of the white fat to maximize its effect.

Laboratory preparation: 3, *-dimethoxybenzyl alcohol is used as the starting material; to obtain the target product; the raw material needs to undergo bromination, Arbuzov rearrangement reaction, Wittig-Horner reaction and demethylation reaction.

Piceatannol but not resveratrol is a very efficient inducer of apoptosis in ex vivo assay with leukemic lymphoblasts of *1 patients suffering from childhood lymphoblastic leukemia (ALL). Piceatannol inhibits TNF-induced NF-B activation and NF-B-mediated gene expression through suppression of IB kinase and p*5 phosphorylation.

Piceatannol inhibits the growth of colorectal cancer cell lines and arrests Caco*2 cells in the S phase of the cell cycle. Sequential treatment with Piceatannol and Ara-C yields synergistic growth inhibitory effects against HL**0 cells because of remarkably increased Ara-CTP formation after Piceatannol preincubation.

Exposure of different-stage PC*3 prostate cancer (CaP) cells to Piceatannol also results in cell-type-specific downregulation of mTOR and its upstream and downstream effector proteins, AKT and eIF*4E-BP1.