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SUMMARY AND EXPLANATION􀄟
The guaiac method was developed by Van Deen in ***4 to detect occult blood. Boas
began to use this method in ***1 to diagnose gastric bleeding. Since that time, numerous
improvements have been introduced which utilize the peroxides activity of heme. However,
in order to get accurate test results, guaiac based tests require that certain foods, drugs,
vitamins and other substances should be avoided before and during the sample collection
period. Several authors have also found that some patients with colorectal cancer or
adenoma tested negative for occult blood because of the lack of sensitivity of guaiac
based methods.��
Subsequent development of latex immunochemical agglutination and of the single radial
immunodiffusion(SRID) and of the reverse-passive hemagglutination(RDHAA)have produced
test methods more sensitive to low concentrations of human occult blood in feces. The
results of clinical studies indicate that test results are positive in only about ****0 percent
of patients with colorectal cancers and only ****0 percent of patients with polyps. Therefore,
a more sensitive means for detecting fecal occult blood is important for the diagnosis of
diseases that result in gastrointestinal bleeding.
FOB test actually detects lower levels of fecal occult blood than the standard guaiac tests
by employing an immunospecific, double-sandwich capture method without any restriction on
foods and drugs.