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Chengdu, Sichuan
Camptothecin is an alkaloid isolated
from the stem wood of the Chinese
tree, Camptotheca acuminata. This
compound selectively inhibits the nuclear enzyme DNA topoisomerase,
type I. Several semisynthetic analogs of camptothecin have
demonstrated antitumor activity.
Product name:
Camptothecin,CPT
CAS No.:********4
Latin
name: Camptotheca
acuminata.Nothapodytes pittosporoide
Part used:
nuts /bark
Appearance:
light
yellow powder
Test method: HPLC
Specification: Camptothecin*8%
Camptothecin99%
Camptothecinis
a naturally occurring alkaloid derived from the
plant Camptotheca acuminata that was identified in an
anticancer drug discovery screen in the
***0s. Camptothecin forms a stable ternary complex,
preventing normal DNA re-ligation, and causes the complex to
collide with the replication fork, leading to
break and
cytotoxicity.
Camptothecins are mainly used
in lung, breast, and brain cancer. However, topotecan is approved
by the USFDA for the treatment of lung and ovarian cancer and
irinotecan is approved for the treatment of colon
cancer.
Product packing:
1kg/bag
Validity period: 2
years
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