Descripción del producto

Common name: Amitraz
Chemical name: 1,*-Di(2,*-dimethylphenyl)**-methyl*1,3,*-triazapenta*1,*-diene; N-Methyl-bis(2,*-xylyliminomethyl)amine                                       Structure formula:
 
Molecular formula: C*9H*3N3
CAS No: *********1
Use: Amitraz is a triazapentadiene compound, a member of the amidine class. It is an insecticide and acaricide used to control red spider mites, leaf miners, scale insects, and aphids in which the mechanism of action is similar to other *-adrenoreceptors agonists as well as by the inhibition of the enzyme monoaminooxidase.

Specification:
Amitraz *8% Min. Technical grade

Amitraz

Common name amitraz (BSI, E-ISO, ANSI, ESA, BAN, JMAF); amitraze ((m) F-ISO)
IUPAC name N-methylbis(2,*-xylyliminomethyl)amine 
Chemical Abstracts name N'-(2,*-dimethylphenyl)-N-[[(2,*-dimethylphenyl)imino]methyl]-N-methylmethanimidamide 
Other names N,N-bis(2,*-xylyliminomethyl)methylamine; N-methyl-N'*2,*-xylyl-N-(N*2,*-xylylformimidoyl)formamidine; 1,*-di-(2,*-dimethylphenyl)**-methyl*1,3,*-triazapenta*1,*-diene  CAS RN [*********1]  EEC no. ********4  Development codes BTS *7 **9 (Boots)  Official codes OMS ***0; ENT *7 **7 

PHYSICAL CHEMISTRY
Mol. wt. **3.4  M.f. C*9H*3N3  Form White/pale yellow crystalline solid.  M.p. ****8   V.p. 0.*4 mPa (*5 ) using clapeyron-clausius analysis  KOW logP = 5.5 (*5 , pH 5.8)  Henry 1.0 Pa m3 mol*1 (measured)  S.g./density 1.**8 (*0 )  Solubility In water <0 .1 mg/l (*0 ). Soluble in most organic solvents; in acetone, toluene, xylene >**0 g/l.  Stability Hydrolysis DT*0 (*5 ) 2.1 h (pH 5), *2.1 h (pH 7), *5.5 h (pH 9). U.V. light appears to have little effect on stability.  pKa 4.2, weak base 

COMMERCIALISATION
History Acaricide reported by B. H. Palmer et al. (Proc. Int. Congr. Acarol. 3rd, ***1, p. **7) for veterinary use and by D. M. Weighton et al. (Meded. Fac. Landbouwwet. Rijksuniv. Gent, ***2, *7, **5) for crop use. Introduced by The Boots Co. Ltd.; (now marketed by Aventis CropScience for crop protection and by Hoechst AG for veterinary use).  Patents GB ******5 (Boots)  Manufacturers Aventis; Defensa; Rotam; Wujin

APPLICATIONS
Biochemistry Mode of action probably involves an interaction with octopamine receptors in the tick nervous system, causing an increase in nervous activity.  Mode of action Non-systemic, with contact and respiratory action. Expellent action causes ticks to withdraw mouthparts rapidly and fall off the host animal.  Uses Control of all stages of tetranychid and eriophyid mites, pear suckers, scale insects, mealybugs, whitefly, aphids, and eggs and first instar larvae of Lepidoptera on pome fruit, citrus fruit, cotton, stone fruit, bush fruit, strawberries, hops, cucurbits, aubergines, capsicums, tomatoes, ornamentals, and some other crops. Also used as an animal ectoparasiticide to control ticks, mites and lice on cattle, dogs, goats, pigs and sheep.  Phytotoxicity At high temperatures, young capsicums and pears may be injured.  Formulation types EC; PO; WP.  Compatibility Incompatible with alkaline materials, parathion, and others.  Selected tradenames: 'Mitac' (for crop protection) (Aventis); 'Ovasyn' (Aventis); 'Byebye' (Agriphar); 'Edrizar' (Caffaro); 'Parsec' (Makhteshim-Agan); 'Racet' (Rotam); 'Sender' (Sanonda); 'Taktic' (for veterinary) (Intervet)

MAMMALIAN TOXICOLOGY
Reviews FAO/WHO *3, *5 (see part 2 of the Bibliography).  Oral Acute oral LD*0 for rats **0, mice >***0 mg/kg.  Skin and eye Acute percutaneous LD*0 for rabbits >**0, rats >***0 mg/kg.  Inhalation LC*0 (6 h) for rats *5 mg/l air.  NOEL In 2 y feeding trials, no adverse effect observed in rats receiving *****0 ppm diet, or in dogs dosed 0.*5 mg/kg daily. Human NOEL >0.**5 mg/kg daily.  ADI (JMPR) 0.*1 mg/kg b.w. [***8].  Toxicity class WHO (a.i.) III; EPA (formulation) III  EC hazard Xn; R*2 

ECOTOXICOLOGY
Birds LD*0 for bobwhite quail **8 mg/kg. LC*0 (8 d) for mallard ducks ***0, Japanese quail ***0 mg/kg.  Fish LC*0 (*6 h) for rainbow trout 0.*4, bluegill sunfish 0.*5 mg/l. Due to rapid hydrolysis, it is unlikely that this toxicity will be expressed in natural aquatic systems.  Daphnia LC*0 (*8 h) 0.**5 mg/l. Due to rapid hydrolysis, it is unlikely that this toxicity will be expressed in natural aquatic systems.  Algae EC*0 for Selenastrum capricornutum >*2 mg/l.  Bees Low toxicity to bees and predatory insects. LD*0 (contact) *0 mg/bee (formulation).  Worms LC*0 (*4 d) for earthworms >***0 mg tech./kg. 

ENVIRONMENTAL FATE
Animals Rapid breakdown leading to excretion as a conjugate of *-amino**-methylbenzoic acid and, to a lesser extent, to N-(2,*-dimethylphenyl)-N'-methylformamidine.  Plants Rapidly degraded, mainly to N-(2,*-dimethylphenyl)-N'-methylformamidine and, to a smaller extent, to 2,*-dimethylformanilide.  Soil/Environment Rapidly broken down in soil under aerobic conditions (J. Appl. Bacteriol., ***7, *2, **7; ibid. ***8, *4, **3); DT*0 in soil <1 d. Degradation occurs more rapidly in acid than in neutral or alkaline soils. Very strongly adsorbed to soil; Koc c. ********0.