agrochemicals supplier fipronil 8% FS 5% SC 5g/l SC 95% TC biochemical

Descripción del producto

agrochemicals supplier fipronil 8% FS 5% SC 5g/l SC *5% TC biochemical

NOMENCLATURE

Common name fipronil (BSI, pa E-ISO)

IUPAC name (?**-amino**-(2,*-dichloro-a,a,a-trifluoro-p-tolyl)**-trifluoromethylsulfinylpyrazole**-carbonitrile  

Chemical Abstracts name *-amino-[2,*-dichloro**-(trifluoromethyl)phenyl]**-[(1R,S)-(trifluoromethyl)sulfinyl]*1H-pyrazole**-carbonitrile  

CAS RN [**********3]  Development codes MB ****0; RPA***0 (both Rhe-Poulenc)  

PHYSICAL CHEMISTRY

Mol. wt. **7.2  M.f. C*2H4Cl2F6N4OS  Form White solid.  M.p. ******1 ; (tech., **5.****3 )  V.p. 3.7 ?***4 mPa (*5 )  KOW logP = 4.0 (shake flask method)  Henry 3.7 ?***5 Pa m3 mol*1 (calc.)  S.g./density 1.****1.**6 (*0 )  Solubility In water 1.9 (pH 5), 2.4 (pH 9), 1.9 (distilled) (all in mg/l, *0 ). In acetone **5.9, dichloromethane *2.3, hexane 0.**8, toluene 3.0 (all in g/l, *0 ).  Stability Stable in water at pH 5 and 7; slowly hydrolysed at pH 9 (DT*0 c. *8 d). Stable to heat. Slowly degrades in sunlight (c. 3% loss after *2 d continuous irradiation); rapidly photolysed in aqueous solution (DT*0 c. 0.*3 d).  

COMMERCIALISATION

History Discovered by Rhe-Poulenc in ***7. Reported by F. Colliot et al., (Proc. Br. Crop Prot. Conf. - Pests Dis., ***2, 1, *9). Introduced by Rhe-Poulenc Agrochimie (now Bayer CropScience) in ***3. Agricultural uses acquired by  AG in ***3.  Manufacturer Shanghai Agrowonderful

APPLICATIONS

Biochemistry Insecticide which acts as a potent blocker of the GABA-regulated chloride channel. Insects resistant or tolerant to pyrethroid, cyclodiene, organophosphorus and/or carbamate insecticides are susceptible to fipronil.  Mode of action Broad-spectrum insecticide, toxic by contact and ingestion. Moderately systemic and, in some crops, can be used to control insects when applied as a soil or seed treatment. Good to excellent residual control following foliar application.  Uses Control of multiple species of thrips on a broad range of crops by foliar, soil or seed treatment. Control of corn rootworm, wireworms and termites by soil treatment in maize. Control of boll weevil and plant bugs on cotton, diamond-back moth on crucifers, Colorado potato beetle on potatoes by foliar application. Control of stem borers, leaf miners, planthoppers, leaf folder/rollers and weevils in rice. Foliar application rates range from ****0 g/ha; soil treatment rates ******0 g/ha. Formulation types EC; FS; GR; SC; UL; WG.  Selected products: 'Prince' (Nissan)

OTHER PRODUCTS

'Ascend' (); 'Blitz' (); 'Chipco Choice' (); 'Cosmos' (); 'Goliath' (); 'Icon' (); 'KB Guepes' (); 'Metis' (); 'Regent' (); 'Termidor' (); 'Texas' (); 'Violin' (); 'Frontline' (veterinary use) (Bayer CropScience) mixtures: 'Cardinal' (+ aldicarb) (); 'Gazette Prince' (+ carbosulfan) (); 'Jumper' (+ guazatine+ triticonazole) (); 'Regent Plus' (+ aldicarb) (); 'Trident' (+ aldicarb) (); 'Zoom' (+ guazatine+ triticonazole) (); 'Amistar-Prince' (+ azoxystrobin) (rice nursery box) (, Nihon Nohyaku, Nissan); 'Delaus-Prince' (+ diclocymet) (Nissan); 'Dr. Oryze-Prince' (+ probenazole) (Meiji Seika, Hokko); 'Fuji-one Prince' (+ isoprothiolane) (Nihon Nohyaku); 'Pika Pika' (+ isoprothiolane+ pyroquilon) (Nihon Nohyaku); 'Vget Prince' (+ tiadinil) (Nihon Nohyaku)

ANALYSIS

Product by hplc with u.v. detection. Residues by glc with ECD.  

MAMMALIAN TOXICOLOGY

Reviews FAO/WHO *9, *1 (see part 2 of the Bibliography).  Oral Acute oral LD*0 for rats *7, mice *5 mg/kg.  Skin and eye Acute percutaneous LD*0 for rats >***0, rabbits **4 mg/kg. Not a skin or eye irritant (OECD criteria). Not a skin sensitiser.  Inhalation LC*0 (4 h) for rats 0.**2 mg/l (tech.; nose only exposure).  NOEL (2 y) for rats 0.5 mg/kg diet; (*8 mo) for mice 0.5 mg/kg diet; (*2 w) for dogs 0.2 mg/kg b.w. daily (combined sexes).  ADI (JMPR) 0.***2 mg/kg b.w. [***0]; group ADI for fipronil and fipronil desulfinyl.  Other Non-mutagenic, non-teratogenic; no adverse effect on reproductive performance. Clinical signs of toxicity consistent with the interaction of the molecule at a neurotransmitter receptor were observed in all species tested, but were completely reversible.  Toxicity class WHO (a.i.) II; EPA (formulation) II